For optimal drug delivery to the lungs, what is the recommended range of particle size?

The recommended range of particle size for optimal drug delivery to the lungs is 0.5 to 5 micrometers. This size range is crucial because particles within this dimension can effectively reach the lower regions of the respiratory tract where the alveoli are located. Particles that are too large, such as those measuring 10 micrometers and above, are more likely to be trapped in the upper airway, including the mouth and throat, limiting their therapeutic benefit.

Conversely, particles smaller than 0.5 micrometers may not be efficiently deposited in the lungs since they can be exhaled easily and may even escape into the atmosphere. Therefore, the range of 0.5 to 5 micrometers is optimal for ensuring that medication is delivered deeply into the lungs, allowing for effective absorption and action in the pulmonary system. This particle size facilitates deposition in the airways and alveoli, enhancing the drug's effectiveness for respiratory conditions.